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Thus, purine catabolism appears to be a homeostatic response of mitochondria to oxidant stress and may protect against progressive mitochondrial dysfunction in certain disease states (Kristal et al., 1999)

Reactive oxygen species (ROS) deposition is a significant driver of, IE as well as one of its effects, which can cause oxidative stress in the erythroid cells

Thus, measurement of GR activity is used as indicator for oxidative stress

Golgi and ER proteins used in Fig

5 Conclusion This work presented a productive and scalable solution for the manufacture of an oncolytic virus using a challenging adherent cell line grown in serum-containing media

These seem to be for local use, perhaps more shorter term storage days/months