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In addition, in response to a single bout of resistance exercise, plasma NO metabolites, nitrate and nitrite, and cyclic guanosine monophosphate (cGMP) were elevated 30 min following exercise [7]
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On the last day, ethanol-fed mice were given a single gavage of ethanol (5 g/kg b.w., 31.25% ethanol), while the pair-fed mice were given an isocaloric gavage of dextrin maltose
However, when the adaptive capacity is overcome, hemolytic erythrocyte-derived products act as signaling molecules, namely DAMPs, which promote inflammation via triggering TLR4-dependent activation of endothelial cells associated with NF-B-mediated synthesis of proinflammatory cytokines, TLR4-independent, ROS-, NADPH oxidase- and heme iron-mediated promotion of neutrophil extracellular traps (NETs) formation, TLR4-dependent activation of macrophages accompanied by secretion of tumor necrosis factor (TNF-), and MyD88/TRIF pathway-mediated TLR4-dependent microglia activation that triggers neuroinflammation [224]
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