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The statistical analysis of the lipophilic fraction (Fig 2B and B) generated a weak OPLS-DA model with only limited class separation (with parameters R 2 = 0.56 and Q 2 = 0.28, CV-ANOVA test, P = 0.6), with a single metabolite (glycerophospholipidssphingomyelin) responsible for the class distinction (Figs 2B, B, and C and S3)

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These symptoms can indirectly affect body weight because low energy often reduces appetite and activity

This depends on how severe the deficiency is and how well the patient responds to treatment

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