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Long-term use of proton pump inhibitors (PPIs) and H2 blockers also reduces stomach acid, impairing B12 release from food

Cell (2006) 126(4):74154

Gut Cell Studies: Moreover, teams use it in vitro to probe gastric and intestinal cell behaviour

partially plausible

PLoS One 8:e74340 Haeusler RA, Hartil K, Vaitheesvaran B, Arrieta-Cruz I, Knight CM, Cook JR, Kammoun HL, Febbraio MA, Gutierrez-Juarez R, Kurland IJ, Accili D (2014) Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors

Animal studies involving surgically severed tendons document measurable improvements in tensile strength and tissue integrity within 14 to 21 days of administration