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Astrocytic autophagy plasticityboosting degradation of pathological proteins Neurons exposed to -amyloid oligomers fail to cope with this proteotoxic stress, leading to a reduction in the expression of autophagy-related genes (MAP1LC3B/LC3B and SQSTM1/p62, two key autophagy-related genes) alongside a decrease in microtubule-associated protein 2 (MAP2)

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In addition, a phase 2 trial (NCT02655601) investigated the use of BMX-001, an inhibitor of NF-kB and HIF-1, in combination with radiotherapy and temozolomide in 160 patients with high-grade glioma [103]

In another study, an -polylysine-bilirubin (PLL-BR) coupling was designed and synthesized to act as a method for bilirubin solubility and delivery

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Alcohol-induced increase in neutrophil activation and NETs was prevented in the livers of BTKi-treated mice