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The absence of validated efficacy data means youre titrating based on subjective experience and hope, not on a known dose-response curve

Possible irregularity from rapid weight loss

Inhibition of miR-223 attenuates the NLRP3 inflammasome activation, fibrosis, and apoptosis in diabetic cardiomyopathy

The 14.9% mean weight loss at 68 weeks was unprecedented for a GLP-1 receptor agonist at the time