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This is supported by studies using neurons differentiated from patient-derived induced pluripotent stem cells (iPSC), which were found to display hyperexcitability and increased intracellular Ca 2+ levels, as well as increased transcription of genes involved in Ca 2+ -signalling, compared with neurons derived from healthy unaffected controls [19, 20]

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Indeed, several studies have proposed that DAM contribute to the clearance of neuronal debris, including synaptic structure, a function inferred from their transcriptional profile as described by Keren-Shaul et al