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Because tumor growth also depends on new blood vessels, several reviews describe this as a theoretical concern that has not been resolved in humans (Sehgal et al., Pharmaceuticals, 2025)

Petrelli, A

In vitro functional analyses confirmed their mature hepatocyte characteristics: they showed high transcription and protein expression of ALB, A1AT, CYP3A4, and CYP2C9, comparable to primary human hepatocytes (PHs)

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10.1002/(SICI)1097-4547(20000215)59:4 3.0.CO;2-9 Summary Keywords zebrafish, hair cell protection, hearing loss, aminoglycosides, hepatocyte growth factor, lateral line Citation Uribe PM, Kawas LH, Harding JW and Coffin AB (2015) Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure