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While AEs associated with these agents have been investigated 19,36,37 , our analysis reveals critical gaps in understanding their NAEs given the central nervous system penetration and expanding indications of GLP-1 RAs

REDEFINE 3 cardiovascular outcomes trial is ongoing (~7,000 participants)

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A 12-week clinical trial (Published in Clinical, Cosmetic and Investigational Dermatology , 2017) found that oral glutathione (250 mg daily) significantly reduced melanin index and improved skin tone and elasticity in women aged 3050