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Introduction Smoking habits and preferences have evolved significantly over the years, influenced by changes in societal norms, health awareness, and technological advancements

Additionally, in human gastric adenocarcinoma, 8-paradol exacerbates PINK1-Parkin-mediated mitophagy to decrease the expression of BCL2, whereas it increases the expression levels of BAX, cytochrome c, and caspase-9/3, ultimately inducing intrinsic apoptosis [26]