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doi: 10.1038/nrgastro.2017.119 46 JiangX.ZhangY.WangH.WangZ.HuS.CaoC.et al

All commercial syntheses are based on the concept of a three-component, one-pot reaction of triamino-pyrimidinone with a three-carbon compound of variable structure (e.g., halogen derivatives of propanal, propanone, and propane) and p -aminobenzoyl-L-glutamic acid to yield folic acid