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In particular, computational approaches, including bioinformatics and machine learning, are being used to better define sequence diversity/conservation across viruses and to aid in antigen design

"The adolescent and adult form of cobalamin C disease: clinical and molecular spectrum"

The following adverse effects were reported in patients receiving semaglutide injection or oral tablets across all clinical trials and at incidences higher than with placebo: nausea (11% to 44%), vomiting (5% to 24%), diarrhea (8.5% to 30%), abdominal pain (5.7% to 20%), abdominal distention (2% to 7%), constipation (3.1% to 24%), dyspepsia (0.6% to 9%), decreased appetite (6% to 9%), eructation (0.6% to 7%), flatulence (0.4% to 6%), gastroesophageal reflux disease (1.5% to 5%), gastroenteritis (4% to 6%), and gastritis (0.4% to 4%)

This means B12 injections are well-tolerated by most people, with minimal risk of side effects

Without that I find the injections virtually pain free

10.1002/dta.3001 [DOI] [PubMed] [Google Scholar] de Ronde W., Smit D