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Acknowledgments Funding was provided by Ardea Biosciences/AstraZeneca

Many models struggle to represent true BBB tightness, show high variability between systems, and may have limited translational value when predicting brain exposure in vivo

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specific values for half-life and tissue retention vary across the literature depending on model and route of administration

it also counteracts the bleeding disorders, amputation, organ perforation, and/or anti-coagulants application or major vessel occlusion (Stupnisek et al., 2012