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In addition, rats treated with linezolid had significantly (p 0.05) lower levels of albumin and higher levels of serum urea and creatinine (2.93 0.175 mg/dL, 1.45 0.034 mg/dL, and 65.38 4.392 mg/dL, respectively) than the control non-treated group (3.92 0.067 mg/dL, 0.45 0.036 mg/dL, and 31.85 1.787 mg/dL, respectively), a finding that suggests compromised kidney function

Mechanistically, siNrf2 transfection reverses these effects, indicating that Nrf2 mediates the proapoptotic effects of Res on fibroblast-like synoviocytes

10, 161 (2017), Application(s): Microplate Reader

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