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Physical activity enhances hippocampal neurogenesis and cognitive function through promoting the increase in the cerebral blood flow [162], BBB permeability [163], angiogenesis [164] and the expression of neurotrophic factors [10]

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The epigenetic mechanisms include methylation and/or demethylation of DNA, post-translational modifications of histones, and non-coding RNAs such as microRNAs (Casanello et al., 2018)

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