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Chen Y et al (2023) The interaction between ferroptosis and inflammatory signaling pathways

Upregulation of ATP7A or exposure to the copper chelator tetrathiomolybdate (TTM) results in reduced phosphorylation of ERK1/2, indicating that copper bioavailability represents a KRAS-selective vulnerability

Specifically, it upregulates genes involved in collagen synthesis (Types I, III, and V), decorin production (which regulates collagen fibril assembly), integrin and glycosaminoglycan synthesis, DNA repair enzymes, antioxidant defense systems (superoxide dismutase, glutathione), and stem cell markers

Elsevier Science: Amsterdam, 2003 , p

PMID 10711406