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Garcia-Lopez, M

Initial Treatment in Combination with Pembrolizumab and Platinum The efficacy of pemetrexed for injection in combination with pembrolizumab and platinum chemotherapy was investigated in Study KEYNOTE-189 (NCT02578680), a randomized, multicenter, double-blind, active-controlled trial conducted in patients with metastatic non-squamous NSCLC, regardless of PD-L1 tumor expression status, who had not previously received systemic therapy for metastatic disease and in whom there were no EGFR or ALK genomic tumor aberrations

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However, these effects are prevented in fasted animals due to a reduction in the increment of the glomerular transcapillary hydrostatic pressure.15 Additionally, a protein-rich diet also stimulates VEGF signaling, which promotes glomerular hypertrophy.84 In contrast, low-protein diet leads to reduced serum GH and IGF-1 levels in rats, which could help preventing glomerulosclerosis.85 It is important to note that appetite-regulating endocrine factors, such as leptin, a hormone that induces satiation, may be linked to IGF-1 production in renal patients

Genetics of obesity in humans

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