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In addition, as suggested by Steiner et al [42], the lack of effect on these parameters could result from the lack of selection of patients who should receive AOXs as well as confounding factors affecting pregnancy rates

As it is already reported that IL-10 can block the activity of NF-kB to downregulate the production of IL-6, we might tend to regard the high levels of IL-10 as negative feedback of counteracting the increase of IL-6