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[117] [16] Nevertheless, nicotine has a relatively high toxicity in comparison to many other alkaloids such as caffeine, which has an LD 50 of 127 mg/kg when administered to mice

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Age-adjusted prevalence of current smoking overall was 15.9% (95% CI 15.2, 16.7) in 1998, decreasing to 11.2% (95% CI 10.412.1) by 2018 (Fig