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In such a study (16-week randomized, double-blind, placebo-controlled), 204 individuals with obesity but not diabetes were treated with self-administered subcutaneous injections of pramlintide (nonforced dose escalation 240 g) or placebo three times a day, 15 minutes before meals without concomitant lifestyle intervention (200)

I did not experience any side effects other then nausea but its definitely tolerable

Deckert J, Wetzel M-C, Bartle LM, Skaletskaya A, Goldmacher VS, Valle F, et al

Probiotics can be found in a variety of fermented foods and beverages