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These protocols form the foundation for current therapeutic dosing recommendations

In addition, MOTS-c treatment significantly increased the phosphorylation level of AMPK and inhibited the activation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), P38, and c-Fos expression induced by formalin (8)

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Current research suggests potential benefits in areas such as growth hormone production, recovery, physical performance, and body composition, but additional long-term studies are needed to better define its role in healthy aging and longevity medicine