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(2022) 64:S28191

Thornton et al., 2003)

Aqueles que no sejam medicamentos aprovados est fora do mbito de atuao da EMA

Structural analysis showed that when human DNMT1 was not bound to DNA, the RFTS domain could bind to the MTase domain directly through a hydrogen bond and bind indirectly through a CXXCBAH1 linker, thus forming an auto-inhibitory conformation

Caenepeel, C

C., ONeill, M., Reiman, D., Tunyasuvunakool, K., Wu, Z., emgulyt, A., Arvaniti, E., Beattie, C., Bertolli, O., Bridgland, A., Cherepanov, A., Congreve, M., Cowen-Rivers, A