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In studies investigating the effects of morroniside on cytotoxicity induced by hydrogen peroxide in human neuroblastoma tumor SH-SY5Y cells, it was observed that morroniside effectively reduced intracellular calcium accumulation, mitigated hydrogen peroxide-induced mitochondrial membrane potential (MMP) disruption, and decreased the percentage of apoptosis triggered by hydrogen peroxide (84)

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Hepatic cancer has not been investigated systematically in any of these trials, but in two of them it has been reported as cause of death, and/or found at biopsy or at autopsy (silymarin = 3.1 %, placebo = 4.5 %, and silymarin = 3.4 %, placebo = 7.1 %, respectively) [115, 116]

2, several of the distributions have very long tails