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Response: While these comments are out of scope for this final rule because they do not relate to the specific proposals, we thank commenters for their suggestions on how to improve the HPT requirements and resources and may consider these comments with respect to future rulemaking, guidance, resources, and/or HPT enforcement process improvement

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If severe, refractory to treatment or in the context of an unwell infant, consider rarer conditions such as acrodermatitis enteropathica (zinc deficiency) and more rarely, Langerhans cell histiocytosis (purpura and petechiae)

J Clin Endocrinol Metab (1998) 83:80713

This deficiency signals via the gutliver axis to suppress the hepatic AMPKPPARA signaling pathway, thereby impairing fatty acid oxidation and exacerbating lipid accumulation in the liver

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