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Indeed, mutations in mtDNA or impairment to the ETC cause mitochondrial dysfunction and energy depletion

doi: 10.1016/j.biopha.2022.113395 161 van de DonkNRichardsonPGMalavasiF

120 In myeloid cell-specific SIRT1 knockout mice, lipid toxicity or LPS stimulation induced more severe hepatic inflammation, elevated pro-inflammatory cytokine levels, and enhanced M1 macrophage polarization, highlighting the critical role of SIRT1 in preserving immune balance

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By inhibiting the IL-6R-JAK/STAT signaling pathway, triptolide impedes tumor cell proliferation, survival, and the inflammatory response, which are critical for cancer progression [980]