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To a mixture of (6R)-3-(5-fluoro-2-(2,2,2-trifluoroethoxy)pyridin-4-yl)-1-(3-hydroxy-3-methylbutan-2-yl)-4,5,6,7-tetrahydro-1H-indazole-6-carboxylic acid (100 mg, 0.23 mmol) in DCM (0.6 mL) was added HATU (102 mg, 0.27 mmol), DIPEA (137 L, 0.79 mmol), and then (4-amino-4-methyltetrahydro-2H-thiopyran 1,1-dioxide hydrochloride (54 mg, 0.27 mmol)

doi:10.5650/jos.55.191

For a nutritional supplement from a preventive point of view, 600mg daily should therefore be a reasonable guideline for healthy people to close this gap

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