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Deficiency reduces insulin sensitivity and increases the risk of atherosclerosis, CVD, T2DM, and hypertension [168,169,170]

Factors such as heterogeneous clinical manifestations, geographic dispersion, limited patient numbers and high disability rates exacerbate these challenges

However, GSH levels were not associated with OM severity, indicating that antioxidant upregulation may not directly translate into clinical mucositis outcomes 38,39

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CSMN #3: 27%, n = 55 mitochondria