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Diabetologia 50 , 625633 (2007)

(Provides pharmacological details on pyridoxine, including its role as a coenzyme in neurotransmitter synthesis and interactions such as the antagonism of levodopa and reduction of phenytoin levels)

Subcutaneous administration achieves brain concentrations twice plasma levels (t 1/2 ~10.5 hr) with no toxicity observed at 15 the therapeutic dose in rats

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The increased cost reflects the longer treatment time, medical supplies, nursing oversight, and the ability to include multiple nutrients in one session

primary models for obesity and mechanistic studies Rats Obese Zucker rats