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Together, these pathways generate a proliferative bias, shifting the -cell compartment toward expansion

The PROactive 294 trial showed that pioglitazone, compared with a placebo, reduced the risk of composite outcomes (all-cause mortality, nonfatal MI and stroke) by 16% in diabetic patients with established ASCVD

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However, population level studies show that most individuals who recover develop only low levels of neutralizing antibodies 3 , indicating that neutralizing antibodies are likely to have a relatively limited impact on resolving disease