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Importantly, we have solved the crystal structure of our potent inhibitors in complex with GSTO1, paving the way for rational design of optimized GSTO1 inhibitors

Acta Biomed, 79 , 205-210

Furthermore, expression of tissue inhibitors of metalloproteinases (TIMPs) is increased by myofibroblasts, leading to reduced extracellular matrix degradation [257, 258]

564 Furthermore, zinc released from corticostriatal terminals may predominantly contribute to the deleterious effects associated with motor and cognitive symptoms in PD, as it acts synergistically with glutamate

The net result of these processes is an increase in serum concentrations, which, by the way, has been demonstrated to escalate the risk and/or severity of ADRs associated to exposure to such drugs (DrugBank Clinical API Plugins, 2024)