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Overall, whether exposures are conducted via NO or WB exposure systems, the TPM concentration resulting from the smoke or aerosol generation must be measured in the breathing zone of the test animals or inside the exposure chamber and recorded, along with the temperature and humidity

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The staggered introduction of plain packaging in the UK may have also gradually desensitised consumers to the new designs

Even when such individuals are included, the results frequently fail to adequately adjust for confounding effects of COPD 8,9

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