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The staining intensity was assessed using the scoring parameters: strong (3), medium (2), and weak (1), and the H -score value ranging from 0 to 300 was calculated according to the formula [53, 54]: H -score = 1* (% cells 1) + 2* (% cells 2) + 3* (% cells 3)

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Both compounds are substrates for P-glycoprotein (P-gp) [109,110,111,112,113,114]

In order to increase the metabolic stability of anti-Brutons Tyrosine Kinase (BTK) PROTACs, Wangs group reported a series of different compounds varying the rigid linker and different cereblon ligands

Abstract Cyanocobalamin (CNCbl), a medicinal form of vitamin B 12 , is resistant to glutathione (GSH), and undergoes intracellular processing via reductive decyanation producing the Co(II)-form of Cbl (Cbl(II)) mediated by the CblC-protein

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