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"Its main function is to bind to the melanocortin-1 receptor in your body, which causes increased melanin production," says Neil Paulvin, DO, an NY-based longevity and regenerative medicine doctor

The risk increases with CMN size, with a recent systematic review reporting no melanoma in 29 patients with small CMN, four melanomas in 828 patients (0.48%) with medium-sized CMN, and 87 melanomas in 5923 patients (1.47%) with large/giant CMNs, translating to a risk ratio of 21.9 (95% CI 8.55-56.3) for large-giant size CMN in comparison to small-medium sized CMNs at 15 years of age

Expression of superoxide dismutase, glutathione peroxidase, and catalase increases[8]

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