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A lack of enzymatic decomposition of extracellular glutamate results in glutamate accumulating at synapses, which is mainly absorbed by excitatory amino acid transporters (EAATs)

Acta Biol Szeged 49: 19-22, 2005

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Q.KongL.LuoJ.et al

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Halogen facilitates the binding with the enzyme because it increases the binding affinity and binding selectivity, and adding halogens to lead during drug development is well recognized to be a general optimizing approach [31]