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In addition, tumors treated with PD-1/PD-L1 blocking antibodies develop resistance through upregulation of CD38 induced by all-trans-retinoic acid and IFN in the tumor microenvironment [47]

The United States Food and Drug Administration (FDA) has already approved about 60 peptide-based medications for various indications, while hundreds of other peptides are under active research for their potential implications [17]

The compound is not FDA-approved and is prohibited in competitive sports

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In conclusion, this study underscores the important role of GADD45 in modulating hepatic lipogenesis through its interaction with SIRT1

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