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This signalling divergence IGF-1R-independent ERK activation vs IGF-1R-dependent Akt/mTOR activation is one of the central research questions in the MGF field and is the mechanistic basis for the functionally distinct roles of MGF (proliferation, satellite cell activation, anti-differentiation) and mature IGF-1 (differentiation, protein synthesis, hypertrophy) in the sequential muscle regeneration programme
or, e.g., n-octyl-beta-D-glucopyranoside, n- dodecyl-beta-D-maltoside, n-tetradecyl-beta-D-maltoside, tridecyl-beta-D-maltoside, sucrose laurate, sucrose stearate, sucrose myristate, sucrose palmitate, sucrose cocoate, sucrose mono-dodecanoate, sucrose mono-tridecanoate, sucrose mono-tetradeca noate, a coco- glucoside, or any of the alkylsaccharides described in US 5,661 ,130 or in WO 2012/112319 which are herein incorporated by reference), a cyclodextrine (e.g., a-cyclodextrin, p-cyclodextrin, y-cyclodextrin, methyl-p-cyclodextrin, hydroxypropyl p-cyclodextrin, or sulfobutylether p- cyclodextrin), N-[8-(2-hydroxybenzoyl)amino]caprylic acid ( preferably a N-[8-(2- hydroxybenzoyl )amino]caprylate, more preferably sodium N-[8-(2- hyd roxybenzoyl )a m i no]caprylate , also referred to as SNAC), a N-[8-(2- hydroxybenzoyl)amino]caprylate derivative (preferably a sodium N-[8-(2- hydroxybenzoyl)amino]caprylate derivative), a thiomer (also referred to as a thiolated polymer
