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There have been also attempts to develop CA IX antibody-drug conjugates, but in these approaches, both linker and drug are equally important as the antibody itself and all three components together determine the outcome of therapy and potential side effects, as it was in the case of the human 3ee9 antibody conjugated to monomethyl auristatin E through a self-cleavable linker (BAY 79-4620), which showed potent antitumor efficacy in several xenograft models [110], but failed in a clinical trial due to inacceptable toxicity

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These are usually gastrointestinal complaints

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Importantly, the pivotal cardiovascular and obesity outcome trials of GLP-1RAs, including the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN), Semaglutide Treatment Effect in People with obesity (STEP), and SURPASS (tirzepatide) programs, did not report clinically meaningful increases in AITD or sustained thyroid dysfunction [7,8,30]

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