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For some people with severe allergies, exposure to an allergen can result in a life threatening reaction called anaphylaxis

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Additionally, NR treatment led to an improvement in the cognitive functions of mice 242,243

Injections of B6 may also be given to patients with impaired gastrointestinal absorption

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This suggests that the dose-escalation schedule used for the 36 mg arm may have been somewhat better optimized to mitigate nausea than the schedule for the 12 mg arm, or that the higher dose groups achieved better gastrointestinal adaptation during the titration period