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Anesthesiology 93(3):619628 Ltsch J, Skarke C, Schmidt H, Rohrbacher M, Hofmann U, Schwab M et al (2006) Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites

Thus, according to patent literature the drug-like 8 and 9 exhibit a very high affinity to the Ang IV binding site named the AT4 receptor

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10.1016/j.ydbio.2010.12.022 194 MuramatsuD.YamaguchiH.MinamisawaY.NiiA

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