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The ligand-occupied GH receptor dimer lacks inherent tyrosine kinase activity but provides docking sites for 2 molecules of JAK2, a cytoplasmic tyrosine kinase of the Janus kinase family

There was an increased incidence of Harderian gland adenomas in males and females in all treatment groups (starting at doses equivalent to 0.002 times the human 5 mg intravenous dose, based on body surface area, mg/m2)