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Ethical approval This article does not contain any studies with human and/or animal participants performed by any of the authors

Moreover, SFN is considered to possess negligible toxic effects and effectively traverses the bloodbrain barrier in mice after intraperitoneal administration, potentially increasing brain-derived neurotrophic factor (BDNF) levels and enhancing dendritic spine density due to its direct impact on neurons, while also providing protection against oxidative stress via the Keap1-Nrf2 pathway (102)

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