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PIAS proteins may affect signaling by (i) inhibiting the DNA-binding activity of STATs, (ii) substrate SUMOylation, or (iii) recruit other transcriptional co-repressors

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In conclusion, Nrf2 activation can reduce intestinal inflammation due to direct control of inflammatory pathways by suppression of ROS production (Wen et al

Results from these integrated computational and experimental studies provide insights into the relative oxidizability of GLRXs cysteines and have implications for the use of GLRX as a therapeutic in settings of dysregulated protein glutathionylation

These peptides have shown promising immunogenicity in laboratory studies and represent candidates for potential inclusion in future tuberculosis vaccines

PD-1 and PD-L1 checkpoint signaling inhibition for cancer immunotherapy: mechanism, combinations, and clinical outcome