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A cohort study involved 18 patients with Lafora disease, 8 treated with metformin, and 10 untreated showed that metformin was effective in reducing seizure severity and frequency (Burgos et al

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Foods containing potassium (such as bananas, oranges, potatoes, and leafy greens) are part of a balanced diet, but avoid making significant dietary changes or taking supplements that increase potassium intake without medical advice, particularly if you have kidney disease or take medications such as ACE inhibitors, ARBs, or potassium-sparing diuretics

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Further studies revealed that USP22 regulated the ubiquitination and proteasomal degradation of silent information regulator 2-related protein 1 (Sirt1) in GMCs, modulated the AGEs/RAGE pathway, and stimulated the expression of FN and TGF-1, which accelerates the fibrosis process in diabetic kidneys[42]