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Another study reported that purines from hepatic macrophages could modulate the activation of NLRP3 inflammasomes through the purinergic receptor P2X7, exerting a significant influence on the progression of ALD and potentially serving as a fresh target for future ALD therapy (Le Dare et al., 2021)

Shi MM, Yang QY, Monsel A, Yan JY, Dai CX, Zhao JY, et al

This anti-metastatic effect was due to the activation of the SP1/caveoli-1 signalling pathway (112, 113)

Zhou, F., Zhang, H., Cong, Z., Zhao, L

Transfection of mGSTA4 in HL-60 cells protects against 4-hydroxynonenal-induced apoptosis by inhibiting JNK-mediated signalling