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The main efficacy outcome measures in the KEYNOTE-177 trial were progression-free survival (PFS) and overall survival (OS), with median PFS demonstrated to be 16.5 months (95% confidence interval [CI], 5.4, 32.4) in the pembrolizumab arm and 8.2 months in the chemotherapy arm (95% CI, 6.1, 10.2)

Moreover, other important chondrocyte-specific proteins, such as Cartilage Oligomeric Matrix Protein, Aggrecan and Cartilage-associated Protein, are produced and secreted at significant levels by chondrocytes at P6

Oral iron chelation therapy was undertaken with increasing doses of deferasirox

It has been suggested that ExPEC virulence might be a by-product of the commensal lifestyle (Malberg Tetzschner et al., 2020)

Therefore, maintaining cell wall integrity by regulation of cell wall hydrolysing/modifying enzymes such as pectin methyl esterase would be prime contributary to sustain the root apical viability against Al stress