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Consistent with the increase in tsh expression (Opitz et al, 2011), slc5a5 and tpo levels were also increased in nrf2a5 homozygous mutants compared with their WT siblings (Fig 2S)

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The resulting overall reduction in magnesium availability causes blood vessels to constrict and may help explain associations between excessive alcohol consumption and hypertension, cardiac problems, and stroke (Romani 2008