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Concomitantly, as pharmacological NPC1 inhibition leads to a reduction in esterified cholesterol due to the lack of cholesterol transport to the ER, this likely contributes to the moderate increase in total cellular cholesterol levels determined biochemically when compared to controls (Supplementary Fig

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RNA-seq and differential gene expression analysis was performed by GeneWiz

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Biochemistry (1999) 38:1695704

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