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Nutritional Deficiencies Shortfalls in B vitamins, especially B12 and folate, along with low magnesium and vitamin D, compromise the neurotransmitter synthesis and mitochondrial energy your brain depends on

Additionally, we classify metabolites according to possible categories of therapeutic intervention, and summarize the latest preclinical and clinical data unveiling the roles of intestinal metabolites in the pathophysiology of major diseases of the gastrointestinal tract, including inflammatory bowel disease, irritable bowel syndrome, colorectal cancer, enteric infection, food allergy, coeliac disease, as well as obesity and metabolic syndrome

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The results are consistently positive and the mechanistic data is compelling, but as of 2026 there are no completed Phase 3 human randomized controlled trials

Effect of tea catechins on gut microbiota in high fat diet-induced obese mice

Modulation of mite antigen-induced immune responses by lecithin-bound iodine in peripheral blood lymphocytes from patients with bronchial asthma