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The multifunctional nanocomposites represented by YMD@MPDA can synergistically alleviate intestinal inflammation and restore tissue function through five major mechanisms: antioxidant stress (MnO 2 nanozymes clear ROS), immune regulation (H 2 S induces M2 polarization of macrophages), barrier repair (upregulation of tight junction proteins), targeted delivery (yeast cell wall-mediated enrichment at inflamed sites), and microbiota reshaping (inhibition of harmful bacteria and promotion of probiotic growth)

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Given the limited evidence base, patients should weigh the financial commitment against the uncertain benefits and prioritise proven interventions first

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