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Despite extensive research and considerable efforts for developing targeted therapies, it is still an alarming condition with a poor prognosis and high mortality

While cysteine was depleted, cystine, kynurenine, cytosine, and dCTP were the most increased metabolites

Down this line, we observed that FA administration induced a transient decrease in FPN expression, while LA supplementation significantly upregulated FPN levels, thereby accelerating mobilization of excessive iron out of tubular cells and reducing intracellular iron overload

Exp Biol Med (Maywood) 2003;228:387395

TABLE 1 The pharmacodynamics changes in various types of cancer by curcumin effect

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